#5121 IGM POSITIVE MINIMAL CHANGE DISEASE: CHARACTERIZING DISEASE SEVERITY AND OUTCOMES

Abstract Background and Aims Minimal change disease (MCD) is the main cause of nephrotic syndrome in pediatric age it responsible for 10-25% cases adults. It characterized by minimal glomerular abnormalities light microscopy, usually without immunoglobulins or complement deposits immunofluorescence (IF). There a subgroup patients that presents with IgM deposition IF, which has been described as more aggressive disease, frequent relapses [1], dependence steroids [2] worse outcomes. Method This retrospective study analyses follow up 50 adult MCD nephrology consult, diagnosis childhood adulthood. They had renal biopsies performed between 2009 2022. We did not include inappropriate biopsy samples, IF positive C1q. compared characteristics (IgM+) negative (IgM-) at diagnosis, well number per year, presentation association steroid-dependence steroid-resistance. Results were 23 (46%) IgM+ group 27 (54%) IgM- group, mean follow-up 10.2± 7.8 years. The was older time (52 (30-74) years vs 15 (13-23) years; p = 0.001) this probably related presentation, younger (12 (5-16) 52 (73-13) 0.001). groups similar sex distribution (IgM+ male n (55.6%) 10 (44.0%); 0.395). no differences diabetes dyslipidemia frequencies two (Diabetes: 1 (4.3%), 3 (11.3%), 0.614; Dyslipidemia: 7 (30.4%), (25.9%), 0.723), but hypertension 2 (8.7%), 9 (33%), 0.046). estimated filtration rate based on creatinine (eGFRcr) higher (124 (104-130) ml/min/1.73 m2 96 (84-111) m2; 0.003), happens due to confounding variable. In regard significantly than 0.61 (0.27-1.00) year; 0.17 (0.01-0.65) 0.011). (65%); 11 (47%); 0.084) steroid-resistance 6 (26%); (11%); 0.270) isolated outcomes different groups, when we analyze composed outcome plus have 21 (91.3%); 14 (51.8%); 0.04; ORR 9.72; IC 95% 2.37-33.33). An patient 9.7 times odd being steroid-dependent steroid-resistant an patient. From our patients, evolved stage 5 chronic kidney dialysis dependency, all those IgM+. One recurrency after transplant. deaths non-related causes, groups. Genetic test 4 results mutations. Only genetic test, mutation´s identification. Conclusion supports evidence MCD's year steroid resistance. Dialysis started seems frequency suggests testing could be important future prognosis prediction treatment options further studies bigger population need done establish relation.